Eco-Friendly Synthesis and Antiviral Evaluation of Quinazoline-Based Heterocyclic Compounds

Shailendra Singh and Bandana Dwivedi

Volume 4 | Issue 1 | Pages 8-13

Abstract

Quinazoline-based heterocyclic compounds are important scaffolds in medicinal chemistry because their molecular structures can be modified to explore diverse biological activities. Selected 2,4-disubstituted quinazoline derivatives have demonstrated in vitro activity against influenza A virus, supporting further investigation of this scaffold for antiviral drug discovery [1,2]. At the same time, the environmental impact of organic synthesis has encouraged the development of greener synthetic methods that minimize hazardous solvents, energy consumption, and chemical waste [3,4].
The present study proposes an integrated approach for the eco-friendly synthesis and antiviral evaluation of selected quinazoline-based heterocyclic compounds. The synthetic investigation will examine suitable lower-hazard reaction media, reduced solvent consumption, and simplified purification. Antiviral activity will be evaluated using an appropriately validated cell-based assay, together with an independent assessment of hostcell cytotoxicity. The compounds will be compared using the half-maximal effective concentration (EC50), half-maximal cytotoxic concentration (CC50), and selectivity index (SI). Environmental performance will be assessed using process mass intensity and the Efactor.

Keywords

Quinazoline, Quinazolinone, Green synthesis, Heterocyclic chemistry, Antiviral activity, Influenza A virus, Medicinal chemistry, Cytotoxicity, Process mass intensity

Citation (APA)

BibTeX